Metastatic Implantation-Related Mechanisms

DPK-DTPE-MI-01
Cancer cell adhesion to organ-specific microvascular endothelium and extracellular matrix substrates in vitro

DPK- DTPE-MI-02
Cancer cell arrest and survival in the microvascular environment of specific target organs in vivo

DPK-DTPE-MI-03
Cancer cell chemotaxis in response to organ-specific tissue-derived factors in vitro

DPK- DTPE-MI-04
Cancer cell invasion through Matrigel in response to organ-specific tissue-derived factors in vitro

Metastatic Growth-Related Mechanisms

DPK-DTPE-MG-01
Cancer cell proliferation in response to organ-specific tissue-derived factors in vitro

DPK-DTPE-MG-02
Intrametastatic in situ neoangiogenesis package including intra/perimetastatic capillary density; intrametastatic necrosis area and percentage of apoptotic and proliferating cancer cells.

DPK-DTPE-MG-03
Cancer cell-induced in vitro neoangiogenesis package including endothelial cell proliferation assay; matrigel tubulization assay; and alphaV-beta3 integrin-mediated migration assay

DPK-DTPE-MG-04
In vivo matrigel plug angiogenesis assay