|
Drug Effect on Host Cell Response to Tumor-Derived Factors
|
 |
Tumor-Induced
Proangiogenic Endothelial Cell Activation
| DPK-
DTHR-AG-01 |
|
Endothelial cell migration
assay |
| DPK-
DTHR-AG-02 |
|
Endothelial cell invasion assay
|
| DPK-
DTHR-AG-03 |
|
Endothelial cell proliferation/apoptosis
assay |
| DPK-
DTHR-AG-04 |
|
Endothelial cell tube formation
assay in matrigel |
| DPK-
DTHR-AG-05 |
|
Flow cytometry of proangiogenic
integrin expression |
| DPK-
DTHR-AG-06 |
|
Proangiogenic integrin-mediated
endothelial cell migration assay |
| DPK-
DTHR-AG-07 |
|
Matrigel plug angiogenesis in
vivo assay (in nude mice) |
|
|
Tumor-Induced
Inflammatory Response
| DPK-DTHR-IR-01 |
|
Cytokine production
by tumor-activated endothelial cells |
| DPK-DTHR-IR-02 |
|
VCAM-1 protein expression by tumor-activated
endothelial cells |
| DPK-DTHR-IR-03 |
|
Tumor cell adhesion assay to tumor-activated
endothelial cells |
| DPK-DTHR-IR-04 |
|
IKKb-alpha in tumor-activated
endothelial cells |
| DPK-DTHR-IR-05 |
|
Endothelial cell invasion assay |
|
|
Tumor-Induced
Osteogenic & Osteolytic Responses
| DPK-DTHR-OO-01
|
|
Alkaline phosphatase
activity assay |
| DPK-DTHR-OO-02 |
|
Osteoblast proliferation assay
|
| DPK-DTHR-OO-03 |
|
Calcium deposition assay in tumor
activated bone marrow stromal cells |
| DPK-DTHR-OO-04 |
|
Osteoclastogenesis/TRAP activity
assay |
| DPK-DTHR-OO-05 |
|
Bone resorption assay |
|
|
Tumor-Induced
Immune Dysfunctional Response
| DPK-DTHR-ID-01
|
|
IFNgamma production
by tumor-activated lymphocytes |
| DPK-DTHR-ID-02 |
|
TRAIL and FAS-ligand expression
by tumor-activated lymphocytes |
| DPK-DTHR-ID-03 |
|
slCAM-1 secretion by tumor cells |
|
|
Tumor-Induced
Fibrogenic & Fibrolytic Responses
| DPK-DTHR-FF-01 |
|
Fibroblast proliferation
assay |
| DPK-DTHR-FF-02 |
|
Collagen production assay by tumor-activated
fibroblasts |
| DPK-DTHR-FF-03 |
|
Fibroblast migration (chemotaxis)
assay |
|
|
Tumor-Induced
Glial Cell Responses
| DPK-DTHR-GR-01 |
|
Astrocyte proliferation
assay |
| DPK-DTHR-GR-02 |
|
Neurotrophin production assay
by tumor-activated glial cells |
| DPK-DTHR-GR-03 |
|
Glial cell migration (chemotaxis)
assay |
|
|
